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Ciliobrevin D

CAS No. 1370554-01-0

Ciliobrevin D( Ciliobrevin D )

Catalog No. M11528 CAS No. 1370554-01-0

Ciliobrevin D is a cell-permeable, reversible, specific inhibitor of cytoplasmic dynein.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Ciliobrevin D
  • Note
    Research use only, not for human use.
  • Brief Description
    Ciliobrevin D is a cell-permeable, reversible, specific inhibitor of cytoplasmic dynein.
  • Description
    Ciliobrevin D is a cell-permeable, reversible, specific inhibitor of cytoplasmic dynein, blocks dynein-dependent microtubule gliding and ATPase activity while sparing kinesin dependent cellular trafficking; selectively affects retrograde transport, inhibits the bidirectional transport of organelles along sensory axons and impairs NGF-mediated regulation of growth cones and axon branches, disrupts spindle pole focusing and kinetochore-microtubule attachment at 10-40 uM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Ciliobrevin D
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Dynein
  • Recptor
    Dynein
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1370554-01-0
  • Formula Weight
    392.62
  • Molecular Formula
    C17H8Cl3N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 5 mg/mL (12.73 mM)
  • SMILES
    N#C/C(C(C1=CC=C(Cl)C=C1Cl)=O)=C(N2)/NC3=C(C=CC(Cl)=C3)C2=O
  • Chemical Name
    2-(7-chloro-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-(2,4-dichlorophenyl)-3-oxopropanenitrile

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sainath R, et al. Dev Neurobiol. 2015 Jul;75(7):757-77. 2. Melemedjian OK, et al. Mol Pain. 2014 Jul 4;10:45. 3. See SK, et al. ACS Chem Biol. 2016 Jan 15;11(1):53-60. 4. Firestone AJ, et al. Nature. 2012 Mar 18;484(7392):125-9.
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